ChemicalBook CAS DataBase List 5-(4-Bromophenyl)-4,6-dichloropyrimidine

5-(4-Bromophenyl)-4,6-dichloropyrimidine synthesis

7synthesis methods

Product Name:5-(4-Bromophenyl)-4,6-dichloropyrimidine
CAS Number:146533-41-7
Molecular formula:C10H5BrCl2N2
Molecular Weight:303.97

Macitentan (Opsumit) is an oral antagonist of ETA and ETB developed by ActelionPharm of Switzerland. The synthesis of 5-(4-Bromophenyl)-4,6-dichloropyrimidine is as follows: Add 5-(4-Bromophenyl) pyrimidine-4, 6-diol into POCl3, refluxed for 8h, POCl3 is distilled off under reduced pressure, then the black viscous residue is poured into ice water, adjust the solution to pH9~10 using potassium carbonate. Then filter off, wash with water and dry processing to afford 5-(4-bromophenyl)-4, 6-dichloropyrimidine.

706811-25-8 Synthesis

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-

706811-25-8
107 suppliers
$12.00/1g

5-(4-Bromophenyl)-4,6-dichloropyrimidine

146533-41-7
319 suppliers
$16.00/1g

Yield:146533-41-7 86%

Reaction Conditions:

with trichlorophosphate in water;N,N-dimethyl-aniline;toluene at 30 - 100; for 5 h;Temperature;

Steps:

3.4 Step four:
200 g of the intermediate 3 obtained in the third step was taken in a 3 L three-necked flask.Add 300g of toluene and 180g of N,N-dimethylaniline, mechanically stirred,230 g of phosphorus oxychloride was added dropwise at 30 ° C, and the temperature was raised to 55 ° C after the addition.After the solid is completely dissolved, the temperature is raised to 100 ° C, the reaction is carried out for 4 h, and then cooled to 25 ° C for use.450 g of water was mixed with 500 g of toluene, and cooled to 25 ° C with stirring.The above-mentioned alternate reaction solution was added, and the process control temperature was 30 ° C.Stir at 30 ° C for 1 h, then stand for stratification, and extract the aqueous phase with toluene several times.The toluene extract and the organic phase are combined, and the combined organic phases are decomposed under reduced pressure.Further, ethanol was added, and the mixture was stirred at 15 ° C for 1.5 hours, suction filtered, and dried.The product 5-(4-bromophenyl)-4,6-dichloropyrimidine 195.6 g, the yield was 86.0%,The liquid chromatographic test results of the obtained product are shown in Figure 2.HPLC purity is 99.93%,The test results came to the Waters 2489-1525 high performance liquid chromatograph produced by Waters.

References:

Zhejiang Pioneer Technology Co., Ltd.;Gao Feifei;Gao Junlong;Zhu Minliang;Lu Wei;Liu Yi CN108997223, 2018, A Location in patent:Paragraph 0056; 0063; 0065; 0070; 0077; 0084; 0091

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1878-68-8 Synthesis