Macitentan impurity A synthesis
- Product Name:Macitentan impurity A
- CAS Number:441798-25-0
- Molecular formula:C17H16Br2N6O4S
- Molecular Weight:560.22
1878-68-8
506 suppliers
$6.00/10g
441798-25-0
25 suppliers
inquiry
Yield:-
Steps:
Multi-step reaction with 7 steps
1.1: thionyl chloride / 3 h / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C
2.2: 24 h / 20 - 32 °C
3.1: sodium / methanol / 18 h / 0 - 20 °C
3.2: 4 h / 20 °C
4.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C
5.1: dimethyl sulfoxide / 48 h / 20 °C
6.1: potassium tert-butylate / 1,2-dimethoxyethane / 0.17 h / 40 °C
6.2: 70 h / 100 °C
7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h
7.2: 2 h / 60 °C
References:
Bolli, Martin H.;Boss, Christoph;Binkert, Christoph;Buchmann, Stephan;Bur, Daniel;Hess, Patrick;Iglarz, Marc;Meyer, Solange;Rein, Josiane;Rey, Markus;Treiber, Alexander;Clozel, Martine;Fischli, Walter;Weller, Thomas [Journal of Medicinal Chemistry,2012,vol. 55,# 17,p. 7849 - 7861]
41841-16-1
218 suppliers
$5.00/5g
441798-25-0
25 suppliers
inquiry
149506-35-4
106 suppliers
$43.00/250mg
441798-25-0
25 suppliers
inquiry
706811-25-8
106 suppliers
$12.00/1g
441798-25-0
25 suppliers
inquiry
146533-41-7
317 suppliers
$16.00/1g
441798-25-0
25 suppliers
inquiry