5-(5-Bromo-pyridin-2-yl)-pyrimidine synthesis

Yield:1088410-73-4 64%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;potassium carbonate in ethanol;water;toluene at 70; for 6 h;Inert atmosphere;

Steps:

1 Synthesis of 2,7-bis [2- (pyrimidin-5-yl) pyridin-5-yl] triphenylene (Compound 3)

In a reaction vessel purged with nitrogen,3.81 g of 2,5-dibromopyridine,1.0 g of 5-pyrimidine boronic acid,20 ml of toluene, 5 ml of ethanol,2 M potassium carbonate aqueous solution 6.1 ml, tetrakis (triphenylphosphine) palladium (0) (0.50 g) was added and heated,And the mixture was stirred at 70 ° C. for 6 hours.After cooling to room temperature, 200 ml of chloroform,100 ml of water was added,An organic layer was collected by performing a liquid separating operation.After washing the organic layer twice with 100 ml of water,It was dehydrated over anhydrous magnesium sulfate,The crude product was obtained by concentration.The crude product was purified by column chromatography [carrier: silica gel, eluent: toluene: ethyl acetate = 10: 1 (v / v)],1.23 g (yield 64%) of a white powder of 5- (3-bromopyridin-6-yl) pyrimidine was obtained.

References:

JP6126577,2017,B2 Location in patent:Paragraph 0114