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ChemicalBook CAS DataBase List 5,7-dichloro-1,6-naphthyridine

5,7-dichloro-1,6-naphthyridine synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / Cooling with ice
2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.5 h / -70 - -60 °C / Inert atmosphere
2.2: -70 - 20 °C

References:

GLAXO GROUP LIMITED;ATKINSON, Francis Louis;BARKER, Michael David;DOUAULT, Clement;GARTON, Neil Stuart;LIDDLE, John;PATEL, Vipulkumar Kantibhai;PRESTON, Alexander George Steven;WILSON, David Matthew WO2011/134971, 2011, A1

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