5-Amino-2-(4-chlorophenoxy)pyridine synthesis
- Product Name:5-Amino-2-(4-chlorophenoxy)pyridine
- CAS Number:75926-64-6
- Molecular formula:C11H9ClN2O
- Molecular Weight:220.65
28232-30-6
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75926-64-6
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Yield:75926-64-6 81%
Reaction Conditions:
with acetic acid;zinc at 20; for 3 h;
Steps:
1.2 Preparation of 6- (4-chlorophenoxy) -3-aminopyridine
2.0 g (8.0 mmol) of 6- (4-chlorophenoxy) -3-nitropyridine was added to a 150 mL three-necked flask,20 mL of AcOH, then 1.37 g (2.1 mmol) of zinc powder was added in portions and reacted at room temperature for 3 h. After completion of the reaction, the solvent was removed by suspending and the aqueous solution of NaOH (5%) was adjusted to pH to neutral. Of ethyl acetate. The organic phase was dried over anhydrous MgSO4 and evaporated to dryness. After column chromatography, 1.3 g of product was obtained as a pale red oil in 81% yield.
References:
CN106543167,2017,A Location in patent:Paragraph 0321; 0322; 0323
106-48-9
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75926-64-6
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$60.00/10mg
4548-45-2
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75926-64-6
26 suppliers
$60.00/10mg