5-broMo-2-(2-Methoxyethoxy)pyridine synthesis
- Product Name:5-broMo-2-(2-Methoxyethoxy)pyridine
- CAS Number:212961-29-0
- Molecular formula:C8H10BrNO2
- Molecular Weight:232.07
39856-50-3
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212961-29-0
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Yield:212961-29-0 86%
Reaction Conditions:
with sodium for 2.5 h;Reflux;
Steps:
5-Bromo-2-(2-methoxyethoxy)pyridine (17-2).
To a stirred solution of sodium (591 mg, 24.6 mmol) in 2-methoxyethanol (20 mL) was added a solution of 5-bromo-2-nitropyridine (17-1, 5.00 g, 24.6 mmol) in 2-methoxyethanol (10 mL) at room temperature. The reaction mixture was stirred at reflux for 2.5 h. The solution was concentrated and the residue was diluted with CH2CI2 and H2O. The organic layer was dried and evaporated under reduced pressure to give 5-bromo-2-(2-methoxyethoxy)pyridine (17-2, 4.9 g) in 86% yield: 1H NMR (500 MHz, CDCl3) δ 8.16 (d, J = 2. 6 Hz, 1 H), 7.64 (dd, J = 8.7, 2.6 Hz, 1 H), 6.72 (d, J = 8.7 Hz, 1 H), 4.43 (t, J = 6.6 Hz, 2 H), 3.73 (t, 2 H), 3.41 (s, 3 H). ESI-MS: m/z 232.0 (M + H)+.
References:
WO2013/82324,2013,A1 Location in patent:Paragraph 00156
53939-30-3
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109-86-4
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212961-29-0
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13466-38-1
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109-86-4
561 suppliers
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212961-29-0
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766-11-0
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109-86-4
561 suppliers
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212961-29-0
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$75.00/250mg
624-28-2
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109-86-4
561 suppliers
$11.00/25g
212961-29-0
32 suppliers
$75.00/250mg