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2-Methoxyethanol structure
Chemical Name:
H2O;EGM;Egme;MECS;Prist;WATER G;dowanol7;TAP-WATER;SOLVENT S;dowanolem
Molecular Formula:
Formula Weight:
MOL File:

2-Methoxyethanol Properties

Melting point:
-85 °C
Boiling point:
124-125 °C(lit.)
0.965 g/mL at 25 °C(lit.)
vapor density 
2.62 (vs air)
vapor pressure 
6.17 mm Hg ( 20 °C)
refractive index 
n20/D 1.402(lit.)
Flash point:
115 °F
storage temp. 
Store at +5°C to +30°C.
Very soluble in acetone, dimethylsulfoxide, and 95% ethanol (quoted, Keith and Walters, 1992).
Miscible with N,N-dimethylformamide, ether, and glycerol (Windholz et al., 1983).
15.7(at 25℃)
green cap
Relative polarity
Mild ethereal.
PH Range
5- 7 at 25 °C
Evaporation Rate
explosive limit
Water Solubility 
λ: 213 nm Amax: 1.00
λ: 240 nm Amax: 0.20
λ: 260 nm Amax: 0.05
λ: 300-400 nm Amax: 0.01
Henry's Law Constant
(x 10-2 atm?m3/mol): 4.41, 3.63, 11.6, 3.09, and 3.813 at 10, 15, 20, 25, and 30 °C, respectively (EPICS, Ashworth et al., 1988)
Exposure limits
TLV-TWA skin 5 ppm (15.5 mg/m3) (ACGIH), 25 ppm (77.5 mg/m3) (OSHA).
Stable, but contact with air may lead to the formation of explosive peroxides. A peroxide test should be carried out before this material is used if it has been exposed to air for some time, especially if it is to be purified by distillation. Contact with strong oxidizing agents may cause fire or explosion. Incompatible with strong bases, ac
CAS DataBase Reference
109-86-4(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances
EWG's Food Scores
NCI Drug Dictionary
distilled water
Proposition 65 List
Ethylene Glycol Monomethyl Ether
NIST Chemistry Reference
Ethanol, 2-methoxy-(109-86-4)
EPA Substance Registry System
2-Methoxyethanol (109-86-4)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H302-H312-H332-H360-H226-H302+H312+H332-H360FD-H370-H373
Precautionary statements  P201-P210-P260-P302+P352+P312-P304+P340+P312-P308+P311-P261-P303+P361+P353-P405-P501a-P280-P370+P378
Hazard Codes  T,F,C
Risk Statements  60-61-10-20/21/22-39/23/24/25-23/24/25-11-35-34-36/38
Safety Statements  53-45-36/37-16-26-23-36/37/39
RIDADR  UN 1188 3/PG 3
WGK Germany  3
RTECS  ZC0110000
Autoignition Temperature 548 °F
HazardClass  3
PackingGroup  III
HS Code  29332990
Toxicity LD50 in rats, guinea pigs (mg/kg): 2460, 950 orally (Smyth); LC50 (7 hr in air) in mice: 4.6 mg/l (Werner)
NFPA 704
1 1

2-Methoxyethanol price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W205605 Amyl alcohol ≥99%, FG 109-86-4 SAMPLE $50 2021-03-22 Buy
Sigma-Aldrich W205605 Amyl alcohol ≥99%, FG 109-86-4 1 kg $64 2021-03-22 Buy
Sigma-Aldrich 1.00859 Ethylene glycol monomethyl ether for analysis EMSURE? ACS,Reag. Ph Eur 109-86-4 1 L $111.92 2021-03-22 Buy
Sigma-Aldrich MX0515 2-Methoxyethanol Meets ACS Specifications GR ACS 109-86-4 500 mL $86.49 2021-03-22 Buy
Sigma-Aldrich W205605 Amyl alcohol ≥99%, FG 109-86-4 4 kg $133 2021-03-22 Buy

2-Methoxyethanol Chemical Properties,Uses,Production


Solvent; jet fuel anti-icing additive; in the semiconductor industry in manufacture of printed circuit boards.


Methoxyethanol is a glycol ether that has been known since the 1920s, but its use significantly increased in the 1970s. Cellosolve was a solvent product containing glycol ethers and registered in the 1920s by Carbide and Carbon Chemicals Corp. Glycol ethers are derived from either ethylene oxide (E-series) or propylene oxide (p-series) combined with an alcohol. Methoxyethanol is an E-series glycol ether derived from methanol and ethylene oxide. Other commonly used glycol ethers include ethoxyethanol, butoxyethanol, and methoxypropanol. Use of methoxyethanol has declined in recent years due to risk management procedures and replacement by other substances.

Chemical Properties

2-Methoxyethanol is a colorless liquid with a slight ethereal odor. The Odor Threshold is 0.92.3 ppm. It is miscible with water and with aliphatic and aromatic hydrocarbons. It is a solvent for essential oils, lignin, dammar, Elemi Essential Oil, ester gum, kauri, mastic, rosin, sandarac resin, shellac, Zanzibar, nitrocellulose, cellulose acetate, alcohol-soluble dyes and many synthetic resins. Its solvency far cellulose esters is augmented when a ketone or a halogenated hydrocarbon i s added. The uses for 2-Methoxyethanol are as a solvent in quick-drying varnishes and enamels, in conjunction with aliphatic, aromatic and halogenated hydrocarbons, alcohols and ketones; in solvent mixtures and thinners for lacquers and dopes; in the manufacture of synthetic resin plasticizers and as a penetrating and leveling agent in dyeing processes, especially in the dyeing of leather, animal and vegetable fibers. Other uses are as o fixative in perfumes and as a solvent in odorless nail-polish lacquers. 2-Methoxyethanol should not be added to nitrocellulose lacquers containing coumarone resins or ester gum because it will cause incompatibility between these substances.

Physical properties

Colorless liquid with a mild, ether-like odor. Experimentally determined detection and recognition odor threshold concentrations were <300 μg/m3 (<96 ppbv) and 700 μg/m3 (220 ppbv), respectively (Hellman and Small, 1974).


2-Methoxyethanol is considered a non-comedogenic raw material. It is used as a solvent in nail products and as a stabilizer in cosmetic emulsions. It is able to penetrate the skin and may cause skin irritation.


The primary use of 2-methoxyethanol is as asolvent for cellulose acetate, certain syntheticand natural resins, and dyes. Other applications are in jet fuel deicing, sealing moisture-proof cellophane, dyeing leather, and use innail polishes, varnishes, and enamels.


Solvent for low-viscosity cellulose acetate, natural resins, some synthetic resins and some alcohol-soluble dyes; in dyeing leather, sealing moistureproof cellophane; in nail polishes, quick-drying varnishes and enamels, wood stains. In modified Karl Fischer reagent: Peters, Jungnickel, Anal. Chem. 27, 450 (1955).


ChEBI: A hydroxyether that is ethanol substituted by a methoxy group at position 2.

General Description

A clear colorless liquid. Flash point of 110°F. Less dense than water. Vapors are heavier than air.

Air & Water Reactions

Flammable. Water soluble.

Reactivity Profile

2-Methoxyethanol is incompatible with oxygen and strong oxidizing agents. Contact with bases may result in decomposition. Incompatible with acid chlorides and acid anhydrides. . 2-Methoxyethanol forms explosive peroxides.


Toxic by ingestion and inhalation. Moderate fire risk. Toxic by skin absorption. Questionable carcinogen.

Health Hazard

2-Methoxyethanol is a teratogen and a chronic inhalation toxicant. The target organs are blood, kidney,and the central nervous system. In addi tion to inhalation, the other routes of expo sure are absorption through the skin, and ingestion. Animal studies indicated that over-exposure to this compound produced anemia, hematuria, and damage to the testes.In humans, inhalation of EGME vapors cancause headache, drowsiness, weakness, irrita tion of the eyes, ataxia, and tremor. The acuteinhalation toxicity, however, is low and anytoxic effect may be felt at a concentration ofabout 25–30 ppm in air
The oral and dermal toxicities of thiscompound in test animals were found to belower than the inhalation toxicity. Ingestioncan produce an anesthetic effect and in alarge dosage can be fatal. An oral intake ofabout 200 mL may cause death to humans.
LC50 value (mice): 1480 ppm/7 h,
LD50 value (rabbits): 890 mg/kg
EGME is a teratogen exhibiting fetotoxi city, affecting the fertility and the litter size,and causing developmental abnormalities inthe urogenital and musculoskeletal systemsin test animals.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, inhalation, shin contact, intraperitoneal, and intravenous routes. Human systemic effects by inhalation: change in motor activity, tremors, and convulsions. Experimental teratogenic and reproductive effects. A skin and eye irritant. Mutation data reported. When used under conditions that do not require the application of heat, thts material probably presents little hazard to health. However, in the manufacture of fused collars which require pressing with a hot iron, cases have been reported showing disturbance of the hemopoietic system with or without neurologcal signs and symptoms. The blood picture may resemble that produced by exposure to benzene. Two cases reported had severe aplastic anemia with tremors and marked mental dullness. The persons affected had been exposed to vapors of methyl "Cellosolve," ethanol, methanol, ethyl acetate, and petroleum naphtha. flame. A moderate explosion hazard. Can react with oxidizing materials to form explosive peroxides. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS. Flammable liquid when exposed to heat or

Potential Exposure

2-Methoxyethanol is used as a jet fuel additive; solvent for protective coating; and in chemical synthesis. Ethylene glycol ethers are used as solvents for resins used in the electronics industry, lacquers, paints, varnishes, gum, perfume; dyes and inks; and as a constituent of painting pastes, cleaning compounds; liquid soaps; cosmetics, nitrocellulose, and hydraulic fluids.


There are no experimental carcinogenicity or cancer epidemiology data relating to this chemical , but some short-term test data are available and are summarized in the section on genetic and related cellular effects.

Environmental Fate

Photolytic. Grosjean (1997) reported an atmospheric rate constant of 1.25 x 10-11 cm3/molecule?sec at 298 K for the reaction of methyl cellosolve and OH radicals. Based on an atmospheric OH concentration of 1.0 x 106 molecule/cm3, the reported half-life of methyl cellosolve is 0.64 d (Grosjean, 1997).
Chemical/Physical. At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent concentration of 342 mg/L. The adsorbability of the carbon used was 132 mg/g carbon (Guisti et al., 1974).


UN1188 Ethylene glycol monomethyl ether, Hazard Class: 3; Labels: 3-Flammable liquid

Purification Methods

Peroxides can be removed by refluxing with stannous chloride or by filtration under slight pressure through a column of activated alumina. 2-Methoxyethanol can be dried with K2CO3, CaSO4, MgSO4 or silica gel, then distilled from sodium. Aliphatic ketones (and water) can be removed by making the solvent 0.1% in 2,4-dinitrophenylhydrazine and allowing to stand overnight with silica gel before fractionally distilling. [Beilstein 1 IV 2375.]

Toxicity evaluation

High acute doses of methoxyethanol have a sedative and hypnotic effect. Kidney and lung damages, accompanied by hemoglobinuria, follow exposures to high doses. Toxicity is attributed to the active metabolites: methoxyacetaldehyde and methoxyacetate. In vitro studies with radiolabeled methoxyethanol indicate that formation of methoxyacetyl-coenzyme A may lead to the formation of methoxyacetyl derivatives of Krebs cycle intermediates. Methoxyacetate produces the same testicular lesions in rodents as does the parent compound, although the immunosuppression elicited by methoxyethanol exposure may depend on the putative metabolite, methoxyacetaldehyde. In both the testicular lesion and the immune suppression, some data suggest that the pattern of cell death termed ‘apoptosis’ may be stimulated. Methoxyacetate stimulates synthesis of progesterone by luteal cells in culture. This disturbance of luteal function may be related to the prolongation of gestation in rodents. Teratogenicity appears to be related to interference by methoxyethanol, or its metabolites, with one carbon metabolism in the synthesis of nucleotide precursors, and can be relieved by administration of other substrates, such as serine and glycine, which also provide substrates for nucleotide synthesis. It has also been suggested that toxicity is mediated through inhibition of flavoprotein dehydrogenase-catalyzed reactions.


Vapors may form explosive mixture with air. Heat or oxidizers may cause the formation of unstable peroxides. Attacks many metals. Strong oxidizers may cause fire and explosions. Strong bases cause decomposition and the formation of toxic gas. Attacks some plastics, rubber and coatings. May accumulate static electrical charges, and may cause ignition of its vapors.

Waste Disposal

Concentrated waste containing no peroxides: discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides: perforation of a container of the waste from a safe distance followed by open burning.

2-Methoxyethanol Preparation Products And Raw materials

Raw materials

Preparation Products

2-Methoxyethanol Suppliers

Global( 352)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 20891 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
career henan chemical co
+86-371-86658258 CHINA 29954 58
13867897135 CHINA 925 58
+86 18953170293
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Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 China 5930 58
Xiamen AmoyChem Co., Ltd
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View Lastest Price from 2-Methoxyethanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-07 2-Methoxyethanol
US $1.00 / g 1g 99 20tons Shanghai Longyu Biotechnology Co., Ltd.
2021-12-01 E2-Methoxyethanol
US $2.60 / KG 1KG 99.5% 5000kg Hebei Crovell Biotech Co Ltd
2021-04-13 2-Methoxyethanol MOE
US $1.00 / PCS 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

2-Methoxyethanol Spectrum

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