5-Bromo-2,4-bis(methylthio)pyrimidine synthesis
- Product Name:5-Bromo-2,4-bis(methylthio)pyrimidine
- CAS Number:60186-81-4
- Molecular formula:C6H7BrN2S2
- Molecular Weight:251.17
36082-50-5
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$5.00/1g
5188-07-8
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$13.00/5g
60186-81-4
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$20.00/1g
Yield:60186-81-4 75%
Reaction Conditions:
in tetrahydrofuran at 0 - 20; for 12 h;
Steps:
1 Preparation of 5-bromo-2,4-dimethylthiopyrimidine:
In a 5 L reaction flask, 300 g of 5-bromo-2,4-dichloropyrimidine (1.31 mol) and 2 L of tetrahydrofuran were added, and the mixture was cooled to 0 ° C, and 184.55 g of sodium thiomethoxide (2.63 mol) was slowly added thereto, and the mixture was slowly warmed to room temperature. After 12 hours, the reaction was quenched with water, the organic layer was separated, ethyl acetate was evaporated. A solid 5-bromo-2,4-dimethylthiopyrimidine 280 g was obtained in a yield of 75%
References:
CN104496913,2018,B Location in patent:Paragraph 0004; 0015-0017