5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine synthesis
- Product Name:5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine
- CAS Number:733039-20-8
- Molecular formula:C9H11BrClN3
- Molecular Weight:276.56
36082-50-5
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$5.00/1g
1003-03-8
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733039-20-8
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$6.00/1g
Yield:733039-20-8 100%
Reaction Conditions:
in 1,4-dioxane at 20; for 6 h;
Steps:
1
To a solution of 5-bromo-2,4- dichloropyrimidine (45.6 g, 200 mmol) in dioxane (400 mL) was added N-cyclopentylamine (20.4 g, 240 mmol) at room temperature. The mixture thus obtained was stirred at room temperature for 6 h. The reaction mixture was then diluted with ethyl acetate and washed with brine and dried over MgSO4. The solvent was evaporated to give the title compound as a light yellow solid (56 g, 100%) which was used in next step without further purification. 1H νMR (500 MHz, DMSO-d6) δ 8.23 (IH, s), 7.37 (IH,
References:
WO2009/85185,2009,A1 Location in patent:Page/Page column 35
930-28-9
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205672-25-9
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733039-20-8
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$6.00/1g
137-43-9
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205672-25-9
223 suppliers
$9.00/250mg
733039-20-8
277 suppliers
$6.00/1g