5-Bromo-2-(cyanomethyl)benzimidazole synthesis
- Product Name:5-Bromo-2-(cyanomethyl)benzimidazole
- CAS Number:1312435-81-6
- Molecular formula:C9H6BrN3
- Molecular Weight:236.07
1575-37-7
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107-91-5
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Yield:1312435-81-6 71%
Reaction Conditions:
at 210; for 0.416667 h;Microwave irradiation;
Steps:
12
To a 4-bromobenzene-1,2-diamine 36 (3.35 g, 17.91 mmol) was added 2-cyanoacetamide (3.31 g, 39.4 mmol), then the reaction mixture was stirred at 210° C. for 25 minutes under microwave irradiation. To the reaction solution was added water, then the reaction solution was extracted with ethyl acetate. The extraction was washed respectively with water and brine, then dried over magnesium sulfate. The solvent was removed under reduced pressure, then the obtained residue was purified by column chromatography to give Compound 37 (3.02 g, 71%).Compound 37; 1H-NMR (DMSO-d6) δ: 4.42 (s, 2H), 7.34 (dd, J=9.0, 2.1 Hz, 1H), 7.52 (d, J=8.7 Hz, 1H), 7.78 (s, 1H), 12.79 (s, 1H)
References:
US2012/253040,2012,A1 Location in patent:Page/Page column 33
105-56-6
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1575-37-7
373 suppliers
$10.00/1g
1312435-81-6
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1575-37-7
373 suppliers
$10.00/1g
1312435-81-6
10 suppliers
inquiry