(5-bromo-2-fluorophenyl)(phenyl)methanol synthesis
- Product Name:(5-bromo-2-fluorophenyl)(phenyl)methanol
- CAS Number:885124-18-5
- Molecular formula:C13H10BrFO
- Molecular Weight:281.12
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Yield:885124-18-5 80%
Reaction Conditions:
with ammonium chloride in tetrahydrofuran at 20; for 18 h;
Steps:
30.A Preparation of 1-methyl-3-phenyl1H-indazole-5-carboxylic acid [1-methyl-2-(4-acetyl-piperazin-1-yl)-ethyl]-amide
(A) To a solution of phenylmagnesium chloride (5.5 ml, 11 mmol, 2M in THF), 5-bromo-2-fluorobenzaldyde (2.03 g, 10 mmol) was added at -78° C. under N2. The reaction was allowed to warm up to RT and stirred at RT for 18 h. The milky suspension was poured into a saturated solution of NH4Cl and extracted 3* with EtOAc. The organic layers were combined, dried over sodium sulfate, and evaporated. The crude mixture was purified via flash chromatography affording (5-bromo-2-fluorophenyl)-phenyl-methanol (intermediate XXXa, 2.235 g, 80% yield) as a colorless oil. M+=281.
References:
US2007/37974,2007,A1 Location in patent:Page/Page column 22
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93777-26-5
369 suppliers
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885124-18-5
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