5-BROMO-2-(METHYLAMINO)PYRIMIDINE synthesis
- Product Name:5-BROMO-2-(METHYLAMINO)PYRIMIDINE
- CAS Number:31402-54-7
- Molecular formula:C5H6BrN3
- Molecular Weight:188.03
32779-36-5
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31402-54-7
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Yield: 100%
Reaction Conditions:
in methanol;water for 72 h;Reflux;
Steps:
18.1
40% Aqueous methylamine solution (35 ml) and methanol (20 ml) were added to 5-bromo-2-chloropyrimidine (3 g, 15.5 mmol) and the resulting mixture was heated to reflux for 3 days. The mixture was cooled, then the solvent was evaporated under reduced pressure, the residue was partitioned with methylene chloride and 1 M sodium hydroxide, the organic layer was dried over magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (3.0 g, 100%) as a white solid.1H-NMR (CDCl3) δ: 2.98 (3H, d, J=5.12 Hz), 5.16 (1H, brs), 8.29 (2H, s).
References:
DAIICHI SANKYO COMPANY, LIMITED US2010/130492, 2010, A1 Location in patent:Page/Page column 93
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31402-54-7
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31402-54-7
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32779-36-5
654 suppliers
$5.00/5g
31402-54-7
117 suppliers
$5.00/100mg