5-broMo-3-ethylpyridin-2-aMine synthesis
- Product Name:5-broMo-3-ethylpyridin-2-aMine
- CAS Number:1037253-14-7
- Molecular formula:C7H9BrN2
- Molecular Weight:201.06
42753-67-3
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Yield:1037253-14-7 1.5 g
Reaction Conditions:
with N-Bromosuccinimide in 1,4-dioxane;water at 0; for 2 h;
Steps:
EE; 62 Example EE:
To a solution of 3-ethylpyridin-2-amine (1.0 g, 8.2 mmol, 1 equiv) in l,4-dioxane (10 mL) and water (2 mL) at 0°C was added NBS (1.45 g, 8.2 mmol, 1 equiv). The resulting mixture was stirring at 0°C for 2h. The reaction was diluted with water (50 mL) and extracted with DCM. The organic phase was separated and concentrated. The residue was purified on a silica gel column (hexane/EtOAc) to afford 5-bromo-3-ethylpyridin-2-amine (1.5 g) as a white solid.
References:
WO2019/177997,2019,A1 Location in patent:Paragraph 00266; 00293
149489-03-2
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