(5-BROMO-3-NITRO-PYRIDIN-2-YL)-METHYL-AMINE synthesis
- Product Name:(5-BROMO-3-NITRO-PYRIDIN-2-YL)-METHYL-AMINE
- CAS Number:70232-59-6
- Molecular formula:C6H6BrN3O2
- Molecular Weight:232.03
67443-38-3
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$5.00/1g
74-89-5
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$13.44/25ML
70232-59-6
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$60.00/50mg
Yield:70232-59-6 100%
Reaction Conditions:
in tetrahydrofuran at 0; for 0.5 h;
Steps:
63.1
63a (3 g, 1.0 eq) is dissolved in THF (13 mL), and then cooled to 0° C. Methylamine solution (2M in THF, 20.8 mL, 3.3 eq), is slowly added to the reaction mixture (exothermic). The reaction mixture is stirred for 30 min at 0° C. and diluted with EtOAc. Organic layer is washed with sat aq sodium bicarbonate. The aqueous layer is re-extracted with EtOAc (2×). The organic phase is washed with brine, dried with MgSO4, filtered and concentrated under reduced pressure to obtain 63b which dried under high vacuum for 16 h (2.95 g, quantative yield).
References:
US2010/261714,2010,A1 Location in patent:Page/Page column 89
4093-88-3
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70232-59-6
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$60.00/50mg
6945-68-2
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74-88-4
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70232-59-6
61 suppliers
$60.00/50mg
67443-38-3
381 suppliers
$5.00/1g
70232-59-6
61 suppliers
$60.00/50mg
15862-37-0
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$6.00/1g
74-89-5
0 suppliers
$13.44/25ML
70232-59-6
61 suppliers
$60.00/50mg