5-BroMo-4-fluoropyridin-2-aMine synthesis
- Product Name:5-BroMo-4-fluoropyridin-2-aMine
- CAS Number:944401-69-8
- Molecular formula:C5H4BrFN2
- Molecular Weight:191
944401-77-8
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944401-69-8
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Yield: 97%
Reaction Conditions:
with N-Bromosuccinimide in acetonitrile at 20; for 1 h;Inert atmosphere;
Steps:
13 2-amino-4-fluoro-5-bromopyridine
To a solution of 2-amino-4-fluoropyridine (75.0 g, 0.67 mol) in dry acetonitrile (700 mL), N-bromosuccinimide (122.8 g, 0.69 mol) was added portion wise upon stirring and cooling in an ice-water bath. The reaction mixture was stirred at r.t. for 1 h. After evaporation under reduced pressure, the residue was thoroughly washed with water (3 x 300 mL), taken up by acetonitrile and evaporated under vacuum yielding the title compound as an off white solid (124 g, 97 %).
References:
UCB BIOPHARMA SPRL;ALEXANDER, Rikki Peter;BROWN, Julien Alistair;DELIGNY, Michael;HEER, Jag Paul;JACKSON, Victoria Elizabeth;JADOT, Sophie;KROEPLIEN, Boris;MAC COSS, Malcolm;SABNIS, Yogesh Anil;SWINNEN, Dominique Louis Léon;VAN HOUTVIN, Nathalie;ZHU, Zhaoning WO2015/86527, 2015, A1 Location in patent:Page/Page column 108
947249-20-9
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944401-69-8
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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944401-69-8
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34941-91-8
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944401-69-8
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1237535-76-0
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$94.25/1g
944401-69-8
102 suppliers
$45.00/50mg