2-AMINO-4-FLUOROPYRIDINE synthesis
- Product Name:2-AMINO-4-FLUOROPYRIDINE
- CAS Number:944401-77-8
- Molecular formula:C5H5FN2
- Molecular Weight:112.11
19798-80-2
548 suppliers
$6.00/1g
944401-77-8
223 suppliers
$17.00/1g
Yield:944401-77-8 90%
Reaction Conditions:
with sodium fluoride in N,N-dimethyl-formamide at 140;Solvent;Reagent/catalyst;Temperature;
Steps:
2
The 28 g 2 - amino -4 - chloro pyridine is added to the 100 ml of N, N - dimethyl formamide in, adding 46 g sodium fluoride, reaction 140 °C reaction 5 - 8 hours, cooling to 80 °C, pressure reducing and recovering the solvent, the residue is added in dichloromethane and saturated salt water distribution, organic phase solvent, ethanol recrystallization to obtain 2 - amino 4 - fluoro pyridine, white solid, 22 g, yield 90%.
References:
Shanghai Lingkai Pharmaceutical Technology Co., Ltd.;Liang Zhujun CN108440402, 2018, A Location in patent:Paragraph 0008; 0020; 0023-0024; 0027-0028; 0031
1237535-76-0
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$94.25/1g
944401-77-8
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$17.00/1g
75279-39-9
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$167.00/250mg
944401-77-8
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$17.00/1g
34941-91-8
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$5.00/1g
944401-77-8
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$17.00/1g
98-98-6
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$5.00/10g
944401-77-8
223 suppliers
$17.00/1g