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50536-58-8

5-bromo-4-methyl-1H-indole-2-carboxylic acid synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: N-Bromosuccinimide / chloroform / 1 h / 10 °C
2: acetic acid; sulfuric acid; lithium bromide; N-Methylpyrrole / 2 h / 60 °C
3: potassium hydroxide / tetrahydrofuran; water

References:

Zhang, Jun;Hu, Yun;Wang, Haiyu;Guo, Aixin;Kong, Jianshe;Ma, Rujian;Wu, Tao;Wang, Yi;Li, Lian-Sheng;Mai, Wanping;Ren, Pingda;Deng, Xiaohu [Organic Process Research and Development,2018,vol. 22,# 1,p. 97 - 102]