5-(difluoromethyl)picolinic acid synthesis
- Product Name:5-(difluoromethyl)picolinic acid
- CAS Number:859538-41-3
- Molecular formula:C7H5F2NO2
- Molecular Weight:173.12
1211540-57-6
28 suppliers
inquiry
859538-41-3
37 suppliers
inquiry
Yield:859538-41-3 100%
Reaction Conditions:
with hydrogenchloride;water at 110; for 1.5 h;
Steps:
16.3 5-(difluoromethyl)picolinic acid
A suspension of 5-(difluoromethyl)picolinonitrile (48 mg, 0.311 mmol) in 12 N aqueous hydrochloric acid (4.3 mL, 140 mmol) was stirred at 110° C. for 1.5 hours. After cooling to ambient temperature, the reaction mixture was concentrated and treated with DIPEA (2 mL). The mixture was concentrated and dried in vacuo to provide the title compound in quantitative yield. LC/MS (ESI+) m/z=174 (M+H)
References:
US2014/213581,2014,A1 Location in patent:Paragraph 0644; 0647
1346148-42-2
9 suppliers
inquiry
859538-41-3
37 suppliers
inquiry
149806-06-4
430 suppliers
$5.00/1g
859538-41-3
37 suppliers
inquiry
131747-68-7
96 suppliers
inquiry
859538-41-3
37 suppliers
inquiry
1221272-81-6
55 suppliers
$40.20/250mg
859538-41-3
37 suppliers
inquiry