ChemicalBook CAS DataBase List 5-Fluoro-6-hydroxyindan-1-one

5-Fluoro-6-hydroxyindan-1-one synthesis

7synthesis methods

Product Name:5-Fluoro-6-hydroxyindan-1-one
CAS Number:917885-01-9
Molecular formula:C9H7FO2
Molecular Weight:166.15

3-(3-fluoro-4-hydroxyphenyl)propionic acid

69888-91-1
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917885-01-9
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Yield:917885-01-9 88%

Reaction Conditions:

with sodium chloride;aluminum (III) chloride at 185; for 0.25 h;

Steps:

90

A mixture of (93) (11.6 g, 63.0 mmol) and AlCl₃ (57 g, 87.6 mmol), NaCl(25g, 483 mmol) was melted and stirred at 185 ⁰C for 15 min, then poured into cold water. The suspended solid was stirred for 10 min before being filtered. The solid was air-dried for 4 hr under vacuum to give 263709 as an off-white solid (9.2 g, 88 %). ¹H EPO NMR/CD₃OD, 5, 7.21 (d, IH), 7.18 (d, IH), 3.02-3.08 (t, 2H), 2.61-2.68 (t, 3H). MS (ES) m/z 165.1.

References:

WO2006/138549,2006,A1 Location in patent:Page/Page column 78-79

83802-71-5 Synthesis