5-Fluoro-8-methoxyquinoline synthesis
- Product Name:5-Fluoro-8-methoxyquinoline
- CAS Number:439-88-3
- Molecular formula:C10H8FNO
- Molecular Weight:177.18
3054-95-3
193 suppliers
$28.00/25g
1978-39-8
178 suppliers
$7.00/1g
439-88-3
34 suppliers
$33.00/100mg
Yield:439-88-3 16 %
Reaction Conditions:
with hydrogenchloride in water at 110;Inert atmosphere;
Steps:
106 Synthesis of 5-fluoro-7-nitroquinoline-8-ol (106)
At room temperature, 5-fluoro-2-methoxyaniline (68a) (1.0 g, 7.08 mmol) was addedHydrochloric acid (6.0M) (10.0mL), the reaction mixture was heated to 110°C,Slowly add inAcrolein diethyl acetal(2.31g, 17.7mmol),Stir for 2 hours,Cool to room temperature, and adjust the pH value of the aqueous phase to about 7-8 with saturated potassium carbonate aqueous solution.The resulting mixture was extracted with ethyl acetate (50.0 mL x 3),The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure.The resulting residue was subjected to silica gel column chromatography(gradient elution, eluent: petroleum ether/ethyl acetate=7/1-4/1) purification,5-Fluoro-8-methoxyquinoline (106a) was obtained (0.20 g, 16% yield).
References:
WO2022/253152,2022,A1 Location in patent:Page/Page column 48; 121
445-83-0
171 suppliers
$21.00/5g
439-88-3
34 suppliers
$33.00/100mg
1978-39-8
178 suppliers
$7.00/1g
56-81-5
1623 suppliers
$5.00/25g
439-88-3
34 suppliers
$33.00/100mg