5-iodo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine synthesis
- Product Name:5-iodo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine
- CAS Number:862729-13-3
- Molecular formula:C7H7IN4
- Molecular Weight:274.06
![4-AMino-5-iodopyrrolo[2,3-d]pyriMidine](/CAS/20150408/GIF/163622-50-2.gif)
163622-50-2
84 suppliers
$13.00/250mg
74-88-4
357 suppliers
$15.00/10g
862729-13-3
53 suppliers
$97.00/100mg
Yield: 50%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide for 8 h;
Steps:
2 7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (cmpd (IIB), step e)
To a solution of 750 mg (2.88 mmol) of 5-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine in 20 mL of dry DMF, 190 μL (3.02 mmol) of methyl iodide and 795 mg (5.76 mmol) of anhydrous potassium carbonate were added. After 8 h the solvent was evaporated, the residue taken up with DCM and washed with water. The organic layer was dried over anhydrous Na2S04 and evaporated again to afford 394 mg (50%) of the title compound. HRMS (ESI) calcd for C7H7N4I [M+H]+ 274.9788, found 274.9788.
References:
NERVIANO MEDICAL SCIENCES S.R.L.;ANGIOLINI, Mauro;BUFFA, Laura;MENICHINCHERI, Maria;MOTTO, Ilaria;POLUCCI, Paolo;TRAQUANDI, Gabriella;ZUCCOTTO, Fabio WO2014/184069, 2014, A1 Location in patent:Page/Page column 34; 35
![4-Amino-7H-pyrrolo[2,3-d]pyrimidine](/CAS/GIF/1500-85-2.gif)
1500-85-2
210 suppliers
$6.00/250mg
862729-13-3
53 suppliers
$97.00/100mg
![4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine](/CAS/GIF/123148-78-7.gif)
123148-78-7
268 suppliers
$8.00/1g
862729-13-3
53 suppliers
$97.00/100mg
![Pyrrolo[2,3-d]pyrimidin-4-ol](/CAS/GIF/3680-71-5.gif)
3680-71-5
415 suppliers
$6.00/1g
862729-13-3
53 suppliers
$97.00/100mg
![4-Chloro-7H-pyrrolo[2,3-d]pyrimidine](/CAS/GIF/3680-69-1.gif)
3680-69-1
852 suppliers
$6.00/1g
862729-13-3
53 suppliers
$97.00/100mg