(5-METHOXY-1H-BENZOIMIDAZOL-2-YL)-METHANOL synthesis

Yield: 100%

Reaction Conditions:

with hydrogenchloride in waterReflux;

Steps:

((5-Methyl-1H-benzimidazole-2-yl)-methanol) 26
(5-Methoxy-1H-benzimidazole-2-yl)-methanol 26 was prepared using the Phillips procedure [1], 4-Methoxy-1,2-phenylenediamine (0.7 g, 5 mmol) was heated under reflux temperature with glycolic acid (0.4 g, 5.25 mmol) in hydrochloric acid (15 mL, 5.5 M) for 6 h. The reaction mixture was cooled to room temperature and ammonia solution was added and the mixture cooled in ice until a bright brown precipitate formed. The resulting solid was recrystallised from aqueous ethanol to give 5-methoxy-1H-benzimidazole-2-yl)-methanol as a bright brown solid Yield 100%.

References:

Alasmary, Fatmah A.S.;Snelling, Anna M.;Zain, Mohammed E.;Alafeefy, Ahmed M.;Awaad, Amani S.;Karodia, Nazira [Molecules,2015,vol. 20,# 8,p. 15206 - 15223] Location in patent:supporting information