5-Methylbenzoxazole-2-amine synthesis
- Product Name:5-Methylbenzoxazole-2-amine
- CAS Number:64037-15-6
- Molecular formula:C8H8N2O
- Molecular Weight:148.16
506-68-3
165 suppliers
$10.00/1g
95-84-1
266 suppliers
$6.00/10g
64037-15-6
63 suppliers
$60.00/250mg
Yield:64037-15-6 93%
Reaction Conditions:
in methanol;
Steps:
5.2.3 General procedure for the synthesis of benzoxazol-2-amino compounds (1b-12b, 25b, 27b-29b)
General procedure: BrCN (2.03g, 17.6mmol, 1.1eq) was slowly added to a solution of 2-aminophenol (16.0mmol, 1.0 eq) in 30mL MeOH. The reaction mixture was stirred overnight at room temperature. Excess BrCN was quenched with saturated Na2CO3 in a fume hood, until the pH value reached ～7. Then, MeOH was evaporated and EtOAc (30mL) was added. The organic phase was washed with water (20mL×2) and brine (20mL), and then it was dried over anhydrous Na2SO4, filtered, and evaporated to give the title compound without further purification.
References:
Li, Dongsheng;Liu, Chao;Jiang, Xinhai;Lin, Yuan;Zhang, Jing;Li, Yan;You, Xuefu;Jiang, Wei;Chen, Minghua;Xu, Yanni;Si, Shuyi [European Journal of Medicinal Chemistry,2021,vol. 209,art. no. 112898]
10531-78-9
141 suppliers
$6.00/250mg
64037-15-6
63 suppliers
$60.00/250mg
10531-78-9
141 suppliers
$6.00/250mg
7664-41-7
523 suppliers
$15.00/100ml
64037-15-6
63 suppliers
$60.00/250mg
95-84-1
266 suppliers
$6.00/10g
64037-15-6
63 suppliers
$60.00/250mg