ChemicalBook CAS DataBase List 5-methylenefuran-2(5H)-one

5-methylenefuran-2(5H)-one synthesis

11synthesis methods

Product Name:5-methylenefuran-2(5H)-one
CAS Number:108-28-1
Molecular formula:C5H4O2
Molecular Weight:96.08406

14300-71-1
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108-28-1
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Yield:108-28-1 82%

Reaction Conditions:

with trifluoroacetic acid in chloroform at 10 - 15; for 2 h;

Steps:

2-3 Preparation of the original pulsatilla
20 g (0.175 mol) of the intermediate Z1 was dissolved in 875 ml of chloroform (dehydrated with 3A molecular sieve),Control temperature 10-15 ° C,53.5 g (0.35 mol) of trifluoroacetic acid was added dropwise, and the reaction was vigorously stirred for 2 hours.The solvent was distilled off (the trifluoroacetic acid was removed at the same time)The original pulverizer was obtained in an amount of 13.8 g, and the yield was 82%.The nuclear magnetic data are as follows: 1H-NMR (400 MHz, CDCl3), δ 7.44 (d, 1H, J = 5.5), 6.30 (m, 1H), 5.27 (s, 1H), 4.90 (d, 1H,J=2.3).

References:

Chongqing Pharmaceutical College;Guo Shengchao;Wang Kun;Lv Junjiang;He Dongxian;Li Yan;Shao Qian CN109705068, 2019, A Location in patent:Paragraph 0039-0040; 0041-0042

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