5-(phenylamino)-1,3,4-thiadiazole-2(3h)-thione synthesis
- Product Name:5-(phenylamino)-1,3,4-thiadiazole-2(3h)-thione
- CAS Number:10253-83-5
- Molecular formula:C8H7N3S2
- Molecular Weight:209.29
Yield:10253-83-5 91%
Reaction Conditions:
with sodium hydroxide in ethanol;Reflux;
Steps:
3.1.3. Synthesis of 5-(R-amino)-1,3,4-thiadiazole-2-sulfanyl Derivatives (2a-2j)
General procedure: Compounds 1a-1j (0.006 mol) were dissolved in absolute ethanol (20 mL). To thereaction mixture, 1 equivalent of NaOH and 1.2 equivalent of CS2 were added. Thereaction mixture was refluxed for 8-10 h and followed up by TLC. The finished reactionmixture was acidified with 20% HCl, and the precipitates were filtered and purified throughrecrystallization in ethanol.
References:
?zkay, Yusuf;Haji Ali, Sazan;Kaplanc?kl?, Zafer As?m;Levent, Serkan;Osmaniye, Derya;Sa?l?k, Begüm Nurpelin [Molecules,2022,vol. 27,# 7,art. no. 2121]
5351-69-9
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103-72-0
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