ChemicalBook CAS DataBase List 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid

3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid synthesis

12synthesis methods

Product Name:3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
CAS Number:500011-86-9
Molecular formula:C9H5BrClN3O2
Molecular Weight:302.51

ETHYL 3-BROMO-1-(3-CHLOROPYRIDIN-2-YL)-1H-PYRAZOLE-5-CARBOXYLATE

500011-92-7
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3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid

500011-86-9
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$8.00/250mg

Yield:500011-86-9 92%

Reaction Conditions:

with water;sodium hydroxide in methanol at 20; for 5.5 h;

Steps:

1.5 Example 1
32 g of ethyl 3-bromo-1- (3-chloropyridin-2-yl) -1H-pyrazole-5-carboxylate was added to the reaction flask,Sodium hydroxide 5.5g,Methanol (110 ml) and water (100 ml)Stirring reaction at room temperature 5.5h,Methanol was distilled off under reduced pressure,The organic layer was extracted with ether,The aqueous phase was acidified with concentrated hydrochloric acid to pH = 2,There is a fixed precipitation,filter,Dried to give 1- (3-chloropyridin-2-yl) -3-bromo-1H-pyrazole-5-carboxylic acid.

References:

Nantong Yaben Chemical Co., Ltd.;Lv, Jian;Niu, Yuehui;Wu, Zhengguang CN106187998, 2016, A Location in patent:Paragraph 0009; 0012

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