Vilanterol Trifenatate synthesis
- Product Name:Vilanterol Trifenatate
- CAS Number:503070-58-4
- Molecular formula:C44H49Cl2NO7
- Molecular Weight:774.78
503068-34-6
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$29.00/500μg
595-91-5
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$15.00/250mg
503070-58-4
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Yield:503070-58-4 92%
Reaction Conditions:
in dichloromethane;tert-butyl alcohol at 5 - 66; for 4 h;Solvent;
Steps:
1-5 Example 1:
The virantra base (8g) and triphenylacetic acid (4.75g) were added to a mixed solvent of 33mL of dichloromethane and 167mL of t-butanol, and the stirring was started to adjust the rotation speed to 400 rpm, using a low temperature thermostat (Shanghai Bilang Instrument Manufacturing Co., Ltd.) is heated to 66 ° C to dissolve, the speed is adjusted to 90 rev / min, set the cooling program, from 66 ° C to 30 ° C process, the cooling rate is 0.3 ° C / min, 30 ° C for 1 hour; The process was carried out at 30 ° C to 5 ° C, the cooling rate was 0.2 ° C / min, and the temperature was kept at 5 ° C for 3 hours. Filtration and drying under vacuum at 40 ° C gave 11.7 g of a white solid, yield 92%, and chemical purity 99.9%.
References:
Anhui Dexinjia Bio-pharmaceutical Co., Ltd.;Xu Kun;Li Xuekun;Lin Jianhua;Zhang Qilong;Wang Honglei CN109574861, 2019, A Location in patent:Paragraph 0013-0022
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503070-58-4
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503068-34-6
127 suppliers
$29.00/500μg
503070-58-4
190 suppliers
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