Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate synthesis

5synthesis methods

Product Name:Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate
CAS Number:51814-17-6
Molecular formula:C17H23NO6
Molecular Weight:337.37

N-(2-ETHOXY-2-OXOETHYL)-BETA-ALANINE ETHYL ESTER

3783-61-7
44 suppliers
$31.80/250mgs:

501-53-1
393 suppliers
$10.00/1g

Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate

51814-17-6
16 suppliers
$181.25/1g

Yield:51814-17-6 98%

Reaction Conditions:

with triethylamine in toluene at 0 - 30; for 6 h;Reagent/catalyst;Temperature;

Steps:

2.A; 2.B A: Preparation of CBZ protected compound

To a solution of 40 g (0.1968 moles) of protected glycine ester and 27.84 g (0.2751 moles) of triethyl amine in 320 mL of toluene was charged 40.17 g (0.2355 moles) of benzyl chloroformate at 0-5 ° C. The resultant reaction mixture was heated to 25-30 ° C and stirred for 6 hrs at 25-30 ° C. Upon completion of the reaction, the reaction mixture was quenched with 200 mL of 1 N HCl, followed by 200 mL of water wash. The organic layers were distilled off completely and swapped with toluene (80 ml) to get CBZ protected compound. Yield: 98%

References:

WO2022/44037,2022,A1 Location in patent:Page/Page column 6-7

623-33-6 Synthesis