N-benzyloxycarbonyl-3-fluoro-4-(4'-phenylpiperazinyl)aniline synthesis
- Product Name:N-benzyloxycarbonyl-3-fluoro-4-(4'-phenylpiperazinyl)aniline
- CAS Number:556801-41-3
- Molecular formula:C24H24FN3O2
- Molecular Weight:405.46
Yield:556801-41-3 81.32%
Reaction Conditions:
with sodium hydroxide in water;acetone at 20;
Steps:
1.3 Preparation of intermediate LT-3 N-benzyloxycarbonyl-3-fluoro-4-(4-phenylpiperazinyl)aniline
1L glass reaction flask at room temperature, adding LT-2 acetone solution (or adding 23.95g LT-2, then adding acetone 400g) prepared in the step 2), introducing cooling water into the jacket, adding 10% sodium hydroxide Aqueous solution (containing 6.36 g of sodium hydroxide) and 21.08 g of benzyl chloroformate.Dropping process control within the temperature below 30 .Bi completed, the reaction was stirred at room temperature, HPLC test endpoint.The reaction was completed, 200mL of purified water was added, stirred for 2 hours, suction filtered, the filter cake was transferred to the reaction flask, washed with water 10% ethanol was stirred three times (500g / 3 solid, yield: 81.32%
References:
CN107286111,2017,A Location in patent:Paragraph 0097; 0115-0118
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