ChemicalBook CAS DataBase List DL-4-Hydroxyphenylglycine methyl ester hydrochloride

DL-4-Hydroxyphenylglycine methyl ester hydrochloride synthesis

4synthesis methods

Product Name:DL-4-Hydroxyphenylglycine methyl ester hydrochloride
CAS Number:56405-21-1
Molecular formula:C9H11NO3
Molecular Weight:181.19

122-87-2
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DL-4-Hydroxyphenylglycine methyl ester hydrochloride

56405-21-1
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Yield:56405-21-1 99%

Reaction Conditions:

in methanol;HCl (gas);

Steps:

300.a [1(R)]-3-amino-N-hydroxy-alpha-(2-methylpropyl)-2-oxo-3-[4-(2-quinolinylmethoxy)phenyl]-1-pyrrolidineacetamide mono(trifluoroacetate

(300a) The p-hydroxy phenyl glycine (74.0 g, 442 mmol) was suspended in methanol (500 mL), cooled in an ice bath and HCl (gas) was bubbled through the reaction mixture for 20 minutes, to give a clear solution. The reaction was stirred at rt for 48 h, concentrated in vacuo to give an oil which was triturated with ethyl ether to give the p-hydroxy phenyl glycine methyl ester (95.8 g, 99%) as a white powder. MS found: (M+H)⁺ =182.

References:

US6057336,2000,A

67-56-1 Synthesis