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1-Cycloheptene-1-carboxylic acid, 2-amino-, ethyl ester synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: sodium hydride / toluene / 0 - 100 °C
2: ammonium acetate / methanol / 20 °C

References:

Massari, Serena;Corona, Angela;Distinto, Simona;Desantis, Jenny;Caredda, Alessia;Sabatini, Stefano;Manfroni, Giuseppe;Felicetti, Tommaso;Cecchetti, Violetta;Pannecouque, Christophe;Maccioni, Elias;Tramontano, Enzo;Tabarrini, Oriana [Journal of Enzyme Inhibition and Medicinal Chemistry,2019,vol. 34,# 1,p. 55 - 74]