5-[3-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2-AMINE synthesis
- Product Name:5-[3-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2-AMINE
- CAS Number:5711-64-8
- Molecular formula:C9H6F3N3O
- Molecular Weight:229.16
Yield:5711-64-8 97%
Reaction Conditions:
with anhydrous Sodium acetate in methanol at 20; for 0.5 h;
Steps:
5.1; 12.1 Synthesis of (1)(E)-2-(3-(trifluoromethyl)benzylidine)hydrazinecarboxamide (1.3 g, 97% yield, white solid):
To a solution of 3-(trifluoromethyl)benzenealdehyde (1 g, 5.7 mmol) and sodium acetate (1.4 g, 17.2 mmol) in MeOH (300 mL), Semicarbazide Hydrochloride 0.96 g, 8.6 mmol) was added. The reaction mixture was stirred at room temperature for 30 minutes. The mixture was concentrated in vacuo, then water (100 mL) was added, and then extracted with ethyl acetate (150 mL) (x3). The combined organic layers were filtered and concentrated in vacuo. The residue was purified by filtration and used in the next reaction.
References:
KR102422881,2022,B1 Location in patent:Paragraph 0201-0204; 0248-0251
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