(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER synthesis
- Product Name:(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
- CAS Number:57561-39-4
- Molecular formula:C8H17NO3
- Molecular Weight:175.23
109-83-1
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24424-99-5
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57561-39-4
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Yield:57561-39-4 100%
Reaction Conditions:
in dichloromethane at 20; for 1 h;
Steps:
8.1 Step 1:
To a solution of 2-(methylamino)ethanol (500 mg, 0.53 ml, 6.66 mmol) in CH2Cl2 (20 ml) was added Boc2O (1.48 g, 6.79 mmol), followed by stirring at room temperature for 1 hour. The reaction solution was extracted with brine and CH2Cl2. The organic layer thus obtained was dried over MgSO4 and filtered. Then, the filtrate was concentrated in vacuo to obtain the object compound (colorless oil, quantitative); 1H NMR (200 MHz, CDCl3) δ 3.74 (q, J= 10.5, 5.2 Hz, 2H) 3.25 (t, J= 5.2 Hz, 2H) 2.91 (s, 3H) 1.45 (s, 9H); mass spectrum m/e (relative intensity) 144 (20) 102 (24) 57 (70) 44 (100).
References:
Korea Research Institute of Bioscience and Biotechnology;Korea Research Institute of Chemical Technology US2009/42872, 2009, A1 Location in patent:Page/Page column 19
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57561-39-4
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57561-39-4
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13734-36-6
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57561-39-4
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109-83-1
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57561-39-4
167 suppliers
$14.00/1g