ChemicalBook CAS DataBase List 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER

1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER synthesis

5synthesis methods

Product Name:1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
CAS Number:5952-93-2
Molecular formula:C6H8N2O2
Molecular Weight:140.14

51105-90-9 Synthesis

51105-90-9
111 suppliers
$9.00/100mg

74-88-4
339 suppliers
$15.00/10g

1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER

5952-93-2
63 suppliers
$60.00/100mg

Yield:5952-93-2 90%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20; for 1 h;

Steps:

131.1 first step 1-methyl-1H-pyrazole-4-carboxylate methyl ester

Methyl pyrazole-4-carboxylate 131a (5 g, 39.65 mmol) was dissolved in N,N-dimethylformamide (50 mL),Potassium carbonate (10.96 g, 79.29 mmol) and methyl iodide (6.19 g, 43.61 mmol) were sequentially added, and the reaction was stirred at room temperature for 1 hour.Water (50 mL) was added, extracted with ethyl acetate (50 mL×3), the organic phases were combined, washed successively with water (50 mL) and saturated sodium chloride solution (50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure.The obtained residue was further separated and purified by silica gel column chromatography (eluent: system A),1-Methyl-1H-pyrazole-4-carboxylate methyl ester 131b (5.04 g) was obtained, yield: 90%.

References:

WO2022/57849,2022,A1 Location in patent:Page/Page column 166-167

5952-92-1 Synthesis