ChemicalBook CAS DataBase List (5R)- 5-Methyl-2-Pyrrolidinone

(5R)- 5-Methyl-2-Pyrrolidinone synthesis

11synthesis methods

Product Name:(5R)- 5-Methyl-2-Pyrrolidinone
CAS Number:21395-93-7
Molecular formula:C5H9NO
Molecular Weight:99.13

(5R)-5-methylpyrrolidmn-2-one is prepared by reacting (5S)-5-(bromomethyl)pyrrolidin-2-one in triethylamine and ethanol hydrogenated over 10% Pd/C catalyst at 50 barpressure.

123-76-2 Synthesis

123-76-2
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21395-93-7
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Yield:96 % ee

Reaction Conditions:

Stage #1: levulinic acidwith ammonium acetate;(S)-Ru(OAc)₂(SEGPHOS) in 2,2,2-trifluoroethanol;Glovebox;
Stage #2: with titanium(IV) isopropylate;hydrogen in 2,2,2-trifluoroethanol at 90; under 45004.5 Torr;Glovebox;Sealed tube;Autoclave;

References:

Chakrabortty, Soumyadeep;Zheng, Shasha;Kallmeier, Fabian;Baráth, Eszter;Tin, Sergey;de Vries, Johannes G. [ChemSusChem,2023]

72479-05-1 Synthesis