6-Azauracil synthesis
- Product Name:6-Azauracil
- CAS Number:461-89-2
- Molecular formula:C3H3N3O2
- Molecular Weight:113.07
![[(aminocarbonyl)hydrazono]acetic acid](/CAS/GIF/928-73-4.gif)
928-73-4
461-89-2
The general procedure for the synthesis of 1,2,4-triazine-3,5(2H,4H)-dione from the compound (CAS: 928-73-4) was as follows: 2-[2-(aminocarbonyl)fluorenylidene] 33.9 g (0.259 mol) and 51 g (1.275 mol) of sodium hydroxide were accurately weighed and dissolved in 150 mL of ethylene glycol. The reaction mixture was stirred continuously for 12 hours at 80 °C using a magnetic stirrer. Upon completion of the reaction, the mixture was cooled to room temperature, 250 mL of methanol was added and allowed to stand for 12 hours to promote crystallization. Subsequent filtration was carried out to recover the solvent to give 41.9 g of wet product. The wet product was dissolved in 60 mL of ultrapure water and the pH of the solution was adjusted with concentrated hydrochloric acid to less than 3. The solution was heated to 80 °C and stirring was maintained for half an hour before it was rapidly cooled to 10 °C with ice brine. The precipitate was collected by filtration and washed well with ultrapure water. Finally, the product was dried under vacuum to give 18 g (0.159 mol, 61.6% yield) of 6-azauracil (CD-2).
928-73-4
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461-89-2
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Yield:461-89-2 61.6%
Reaction Conditions:
with sodium hydroxide in methanol;1,2-dimethoxyethane at 80; for 24 h;
Steps:
2.2 (2) Synthesis of 6-azauracil (CD-2)
Weigh 2-[2-(aminocarbonyl) fluorenylene]33.9 g (0.259 mol) and sodium hydroxide 51 g (1.275 mol)Soluble in 150mlIn ethylene glycol,The mixture was stirred under magnetic stirring at 80 ° C for 12 h.After cooling by cooling water,Add 250ml of methanol,Allow to stand for 12h,After suction filtration,Solvent recovery,41.9 g of wet product were obtained,Dissolved in 60ml of water,Adjust pH to pH <3 with hydrochloric acid,Then heated to 80 ° C, After stirring for half an hour,Cool down to 10 ° C with ice brine.After suction filtration and rinsing with ultrapure water,Vacuum drying gave 6-aza-uracil (CD-2) 18 g (0.159 mol, yield: 61.6%).
References:
Central South University;Zhong Shian;Peng Wei;Chen Jian;Liu Hui;Li Xiufang;Li Jianbing;Tang Rongdi CN108440505, 2018, A Location in patent:Paragraph 0089; 0102; 0103; 0104
![3,5-Dihydroxy-[1,2,4]triazine-6-carboxylic acid](/CAS/GIF/13924-15-7.gif)
13924-15-7
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461-89-2
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626-08-4
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461-89-2
250 suppliers
$8.00/1g