6-(BENZYLOXY)NICOTINALDEHYDE synthesis
- Product Name:6-(BENZYLOXY)NICOTINALDEHYDE
- CAS Number:635712-99-1
- Molecular formula:C13H11NO2
- Molecular Weight:213.23
100-39-0
439 suppliers
$10.00/10g
106984-91-2
145 suppliers
$7.00/100mg
635712-99-1
40 suppliers
inquiry
Yield:635712-99-1 88%
Reaction Conditions:
with silver carbonate in acetonitrile at 20;
Steps:
3.a (a) 6-Benzyloxynicotinaldehyde
Benzyl bromide (500 mg, 2.92 mmol) was added to a mixture of 6-hydroxynicotinaldehyde (300 mg, 2.44 mmol), Ag2C03 (1.0 g, 3.66 mmol) and MeCN (15 mL). The mixture was stirred at rt overnight, filtered and concentrated. The residue was partitioned between H2O and EtOAc and the organic layer was washed with H2O, brine, dried over MgSCU and concentrated. The residue was purified by chromatography to give the sub-title compound (455 mg, 2.14 mmol, 88 %).
References:
WO2019/53427,2019,A1 Location in patent:Page/Page column 49
83664-33-9
110 suppliers
$13.00/1g
144-55-8
1355 suppliers
$10.00/25g
635712-99-1
40 suppliers
inquiry
100-51-6
1433 suppliers
$5.00/100g
635712-99-1
40 suppliers
inquiry
624-28-2
734 suppliers
$5.00/5g
635712-99-1
40 suppliers
inquiry