6-(BENZYLOXY)NICOTINALDEHYDE synthesis
- Product Name:6-(BENZYLOXY)NICOTINALDEHYDE
- CAS Number:635712-99-1
- Molecular formula:C13H11NO2
- Molecular Weight:213.23
100-39-0
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Yield:635712-99-1 88%
Reaction Conditions:
with silver carbonate in acetonitrile at 20;
Steps:
3.a (a) 6-Benzyloxynicotinaldehyde
Benzyl bromide (500 mg, 2.92 mmol) was added to a mixture of 6-hydroxynicotinaldehyde (300 mg, 2.44 mmol), Ag2C03 (1.0 g, 3.66 mmol) and MeCN (15 mL). The mixture was stirred at rt overnight, filtered and concentrated. The residue was partitioned between H2O and EtOAc and the organic layer was washed with H2O, brine, dried over MgSCU and concentrated. The residue was purified by chromatography to give the sub-title compound (455 mg, 2.14 mmol, 88 %).
References:
WO2019/53427,2019,A1 Location in patent:Page/Page column 49
83664-33-9
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624-28-2
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