6-(benzyloxy)pyridin-3-amine synthesis
- Product Name:6-(benzyloxy)pyridin-3-amine
- CAS Number:75926-65-7
- Molecular formula:C12H12N2O
- Molecular Weight:200.24
75926-54-4
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Yield:75926-65-7 100%
Reaction Conditions:
Stage #1: 2-(benzyloxy)-5-nitropyridinewith ammonium chloride in tetrahydrofuran;water at 75; for 0.5 h;
Stage #2: with water;iron in tetrahydrofuran at 75;
Steps:
Synthesis of 6-Benzyloxy-pyridin-3-ylamine
Synthesis of 6-Benzyloxy-pyridin-3-ylamine Ammonium chloride (325 mg, 6.0 mmol) in water (10 mL) was added to a solution of 2-benzyloxy-5-nitro-pyridine (350 mg, 1.5 mmol) in THF (15 mL) and the resulting mixture stirred at 75° C. for 30 minutes. Iron powder (340 mg, 6 mmol) was then added portion wise and the mixture stirred for 5 hours at 75° C. The reaction mixture was filtered over celite. The filtrate was basified with sodium bicarbonate solution and the product extracted with ethyl acetate. The organics were washed with brine solution, dried over Na2SO4 and concentrated to afford 320 mg (100%) of 6-benzyloxy-pyridin-3-ylamine.
References:
US2009/239848,2009,A1 Location in patent:Page/Page column 22
5350-93-6
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20194-18-7
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75926-65-7
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5350-93-6
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20194-18-7
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100-51-6
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75926-65-7
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4548-45-2
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75926-65-7
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100-51-6
1446 suppliers
$5.00/100g
75926-65-7
31 suppliers
$40.00/25mg