6-Bromo-1-chloroisoquinoline synthesis
- Product Name:6-Bromo-1-chloroisoquinoline
- CAS Number:205055-63-6
- Molecular formula:C9H5BrClN
- Molecular Weight:242.5
119-65-3
388 suppliers
$5.00/25g
205055-63-6
202 suppliers
$24.00/250mg
Yield:205055-63-6 62%
Reaction Conditions:
in ethyl acetate;trichlorophosphate
Steps:
90.A 6-Bromo-1-chloroisoquinoline
Example 90A 6-Bromo-1-chloroisoquinoline A solution of 6-bromo-1-hydroxy]isoquinoline (9.205 g, 41.0 mmol) in POCl3 (100 mL) was heated to 100° C. for 4 h. The reaction was concentrated to dryness. The residue was dissolved in ethyl acetate and the organic layer was washed with 5% NaHCO3, water, brine, dried over MgSO4 and concentrated. The residue was was chromatographed on silica gel eluding with CH2Cl2:hexane (3:7) to give the title compound (6.176 g, 62%). MS (DCI/NH3) m/z 241, 243 (M+1)+.
References:
Li, Qun;Woods, Keith W.;Zhu, Gui-Dong;Fischer, John P.;Gong, Jianchun;Li, Tongmei;Gandhi, Virajkumar;Thomas, Sheela A.;Packard, Garrick K.;Song, Xiaohong;Abrams, Jason N.;Diebold, Robert;Dinges, Jurgen;Hutchins, Charles;Stoll, Vincent S.;Rosenberg, Saul H.;Giranda, Vincent L. US2003/187026, 2003, A1
223671-16-7
12 suppliers
$70.00/100mg
205055-63-6
202 suppliers
$24.00/250mg
82827-09-6
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$19.00/250mg
205055-63-6
202 suppliers
$24.00/250mg
34784-05-9
318 suppliers
$5.00/1g
205055-63-6
202 suppliers
$24.00/250mg