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ChemicalBook CAS DataBase List 6-bromo-2-fluoro-3-iodopyridine
1599474-54-0

6-bromo-2-fluoro-3-iodopyridine synthesis

3synthesis methods
144100-07-2 Synthesis
2-Bromo-6-fluoropyridine

144100-07-2
241 suppliers
$10.00/5g

6-bromo-2-fluoro-3-iodopyridine

1599474-54-0
31 suppliers
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Yield:1599474-54-0 82%

Reaction Conditions:

Stage #1: 2-bromo-6-fluoropyridinewith lithium diisopropyl amide in tetrahydrofuran at -78; for 1 h;Inert atmosphere;
Stage #2: with iodine in tetrahydrofuran at -78 - -60; for 1.5 h;Inert atmosphere;

References:

Barl, Nadja M.;Sansiaume-Dagousset, Elodie;Monzon, Gabriel;Wagner, Andreas J.;Knochel, Paul [Organic Letters,2014,vol. 16,# 9,p. 2422 - 2425] Location in patent:supporting information