6-Bromo-4-methoxyquinoline synthesis
- Product Name:6-Bromo-4-methoxyquinoline
- CAS Number:874792-20-8
- Molecular formula:C10H8BrNO
- Molecular Weight:238.08
65340-70-7
124-41-4
874792-20-8
At room temperature, 6-bromo-4-chloroquinoline (12.12 g, 50 mmol) was dissolved in methanol (200 mL) followed by addition of sodium methanolate (13.50 g, 250 mmol). The reaction mixture was transferred to a sealed reaction flask, heated to 120 °C and maintained for 15 hours. After completion of the reaction, it was cooled to room temperature and methanol was removed by distillation under reduced pressure. The residue was diluted with water and the resulting solid was collected by filtration and washed with deionized water. The solid was dried over air to give 10.8 g of 6-bromo-4-methoxyquinoline in 90.8% yield as a white solid. The product could be further purified by acetonitrile recrystallization.EI-HRMS analysis result: m/e calculated value C10H8BrNO (M+) 236.9789, measured value 236.9784.
65340-70-7
274 suppliers
$7.00/250mg
124-41-4
726 suppliers
$12.00/25g
874792-20-8
70 suppliers
$41.00/100mg
Yield:874792-20-8 96%
Reaction Conditions:
in methanol at 100; for 2.5 h;Inert atmosphere;Microwave irradiation;
References:
Scheufler, Clemens;M?bitz, Henrik;Gaul, Christoph;Ragot, Christian;Be, Céline;Fernández, César;Beyer, Kim S.;Tiedt, Ralph;Stauffer, Frédéric [ACS Medicinal Chemistry Letters,2016,vol. 7,# 8,p. 730 - 734] Location in patent:supporting information
67-56-1
782 suppliers
$9.00/25ml
65340-70-7
274 suppliers
$7.00/250mg
124-41-4
726 suppliers
$12.00/25g
874792-20-8
70 suppliers
$41.00/100mg
927801-23-8
72 suppliers
$32.00/250mg
124-41-4
726 suppliers
$12.00/25g
874792-20-8
70 suppliers
$41.00/100mg
145369-94-4
223 suppliers
$10.00/250mg
874792-20-8
70 suppliers
$41.00/100mg