6-Bromo-5-fluoroindole synthesis
- Product Name:6-Bromo-5-fluoroindole
- CAS Number:259860-08-7
- Molecular formula:C8H5BrFN
- Molecular Weight:214.03
1034894-73-9
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Yield: 89%
Reaction Conditions:
with iron;acetic acid in ethanol at 90;
Steps:
The enamine (1.89 g, 4.38 mmol) was dissolved in EtOH (35.0 ml_). To this solution Fe (4.42 g, 79.0 mmol) and acetic acid (35.0 ml_) were added and the mixture was stirred at 90 °C for overnight. The resulting mixture was filtered and concentrated. The residue was purified by column chromatography (ethyl acetate-hexane; 1 :9) to afford 6- bromo-5-fluoro-1 H-indole as a yellow solid (0.83 g, 89%). 1H NMR (CDCI3, 400 MHz): 6.52 (m, 1 H), 7.27 (m, 1 H), 7.38 (d, J = 9.3 Hz, 1 H), 7.57 (d, J = 5.7 Hz, 1 H), 8.18 (br. s, 1 H).
References:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS WO2008/77138, 2008, A1 Location in patent:Page/Page column 77
224185-19-7
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259860-08-7
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$33.00/250mg
259860-00-9
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259860-08-7
134 suppliers
$33.00/250mg