ChemicalBook CAS DataBase List 4-Bromo-5-fluoro-2-nitrotoluene

4-Bromo-5-fluoro-2-nitrotoluene synthesis

4synthesis methods

Product Name:4-Bromo-5-fluoro-2-nitrotoluene
CAS Number:224185-19-7
Molecular formula:C7H5BrFNO2
Molecular Weight:234.02

446-33-3
253 suppliers
$17.00/5g

224185-19-7
191 suppliers
$7.00/1g

Yield:224185-19-7 83%

Reaction Conditions:

with sulfuric acid;bromine;silver nitrate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate

Steps:

7.a Synthesis of 4-bromo-5-fluoro-2-nitrotoluene
Example 7a Synthesis of 4-bromo-5-fluoro-2-nitrotoluene A mixture of 5-fluoro-2-nitrotoluene (1.00 g), silver nitrate (2.21 g), bromine (0.37 ml) and conc. sulfuric acid (6 ml) was stirred for 1 hour under cooling with ice. The reaction mixture was added dropwise to ice water and then subjected to extraction with chloroform. The organic layer was washed with saturated sodium hydrogencarbonate solution, dried with anhydrous magnesium sulfate and then concentrated at reduced pressure to give the titled compound in admixture with its regioisomer at a ratio of 5:3 (yield, 83%). ¹H-NMR (CDCl₃) δ:2.77(3H,s), 7.39(1H,d,J=11.0 Hz), 8.82(1H,d,J=7.1 Hz)

References:

Chugai Seiyaku Kabushiki Kaisha US6414005, 2002, B1

FullText

452-74-4 Synthesis