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ChemicalBook CAS DataBase List 6-Bromoisatin
6326-79-0

6-Bromoisatin synthesis

10synthesis methods
Acetamide, N-(3-bromophenyl)-2-(hydroxyimino)-

65971-74-6

6-Bromoisatin

6326-79-0

Step 2: N-(3-bromophenyl)-2-hydroxyiminoacetamide (55 g, 0.2272 mol) was added to concentrated sulfuric acid (275 mL) and the temperature was maintained at 50 °C. The temperature of the reaction system was then raised to 90 °C for 3 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ice water and a yellow precipitate was precipitated. The precipitate was collected by filtration and dried to give 6-bromodihydroindole-2,3-dione as a yellow solid (50 g, 98% yield). The resulting product can be used directly in the subsequent reaction without further purification.

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