6-Hydroxy-2-(methoxymethyl)-4(3H)-pyrimidinone synthesis
- Product Name:6-Hydroxy-2-(methoxymethyl)-4(3H)-pyrimidinone
- CAS Number:1903-90-8
- Molecular formula:C6H8N2O3
- Molecular Weight:156.14
3122-73-4
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$215.61/1gm:
105-53-3
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$5.00/25g
1903-90-8
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$236.81/1gm:
Yield:1903-90-8 85%
Reaction Conditions:
with sodium methylate in methanol at 80;
Steps:
43.a a) 2-(Methoxymethyl)pyrimidine-4,6-diol
diethyl malonate (5 g, 31.22mmol) and 2-methoxyethanimidamide (2.75 g, 31.2 mmol) in methanol (50 mL) and sodium methoxide (14 g, 64.8 mmol) was slowly added and heated at 80oC overnight. title compound (5.2 g, 85%) LRMS (m/z): 157 (M+1)+.
References:
EP2489663,2012,A1 Location in patent:Paragraph 0400; 0401; 0402
1903-91-9
73 suppliers
$97.68/1g
105-53-3
783 suppliers
$5.00/25g
1903-90-8
13 suppliers
$236.81/1gm:
3938-96-3
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$10.00/5g
108-13-4
272 suppliers
$9.00/1g
1903-90-8
13 suppliers
$236.81/1gm: