6-(IsopropylaMino)pyridine-3-carbonitrile synthesis
- Product Name:6-(IsopropylaMino)pyridine-3-carbonitrile
- CAS Number:160017-00-5
- Molecular formula:C9H11N3
- Molecular Weight:161.2
33252-28-7
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160017-00-5
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Yield:160017-00-5 81%
Reaction Conditions:
at 80; for 12 h;Sealed tube;Neat (no solvent);
Steps:
15.1
Step 1: 6-(Isopropylamino)nicotinonitrile (68). A mixture of isopropylamine (15.4 mL, 180.4 mmol) and 47 (5.0 g, 36.2 mmol) was heated in a sealed tube at 80° C. for 12 h. The reaction mixture was then cooled and concentrated. Water was added to the residue and the resulting aqueous mixture was extracted with ethyl acetate. The organic layer was washed with sat. NaCl, dried and concentrated to afford 68 (4.74 g, 81%) as a colorless oil which was used as such for the next step.
References:
US2010/249071,2010,A1 Location in patent:Page/Page column 56-57
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139585-70-9
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