6-Nitro-2H-benzo[b][1,4]thiazin-3(4H)-one synthesis
- Product Name:6-Nitro-2H-benzo[b][1,4]thiazin-3(4H)-one
- CAS Number:21762-74-3
- Molecular formula:C8H6N2O3S
- Molecular Weight:210.21
6283-25-6
271 suppliers
$10.00/25g
2365-48-2
361 suppliers
$14.00/25g
21762-74-3
14 suppliers
$33.28/250mg
Yield:21762-74-3 11%
Reaction Conditions:
with sodium hydroxide in ethanol;water; for 16 h;Reflux;
Steps:
97.A Step A. 6-Nitro-2H-benzo[b][1,4]thiazin-3(4H)-one
A mixture of 2-chloro-5-nitroaniline (15 g, 87 mmol), methyl 2-mercaptoacetate (13.8 g, 130 mmol) and sodium hydroxide (10.4 g, 261 mmol) in EtOH/water (250 mL, v/v=10:1) was heated at reflux for 16 h. The reaction mixture was cooled to ambient temperature, the solvent was removed in vacuo and the residue was purified by column chromatography on silica gel (eluting with 17% EtOAc in petroleum ether) to give 6-nitro-2H-benzo[b][1,4]thiazin-3(4H)-one (2.1 g, 11%). LC/MS (Table 1, Method 2) Rt=0.790 min; MS m/z: 211 [M+H]+.
References:
US2014/206663,2014,A1 Location in patent:Paragraph 1180; 1181
369-36-8
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$10.00/10g
2365-48-2
361 suppliers
$14.00/25g
21762-74-3
14 suppliers
$33.28/250mg
2365-48-2
361 suppliers
$14.00/25g
97-00-7
25 suppliers
$17.67/10gm:
21762-74-3
14 suppliers
$33.28/250mg
6283-25-6
271 suppliers
$10.00/25g
623-51-8
239 suppliers
$7.00/25g
21762-74-3
14 suppliers
$33.28/250mg