6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid synthesis
- Product Name:6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid
- CAS Number:37972-69-3
- Molecular formula:C5H4N2O3
- Molecular Weight:140.1
27372-38-9
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37972-69-3
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Yield:37972-69-3 73%
Reaction Conditions:
with pyridine;copper diacetate;sodium carbonate in toluene at 100; for 16 h;Inert atmosphere;
Steps:
352 6-oxo-1,6-dihydropyridazine-3-carboxylic acid
6-oxo-1,6-dihydropyridazine-3-carboxylic acid
To a solution of 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid (2.50 g, 17.59 mmol) in toluene (44 mL) was added Cu(OAc)2 (450 mg, 2.48 mmol), sodium carbonate (7.01 g, 66.14 mmol) and pyridine (4.4 mL) at room temperature.
The resulting solution was stirred for 16 h at 100° C.
After the reaction was done, the insoluble solids in the reaction mixture were filtered out and the filtrate was concentrated under reduced pressure to yield 6-oxo-1,6-dihydropyridazine-3-carboxylic acid as a off-white solid (1.80 g, 73%). MS: m/z=177.0 [M+H]+.
References:
US2016/376283,2016,A1 Location in patent:Paragraph 1225; 1226
328-50-7
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37972-69-3
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13327-27-0
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37972-69-3
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1121-79-5
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37972-69-3
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