6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE synthesis
- Product Name:6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE
- CAS Number:386704-12-7
- Molecular formula:C7H4F3NO
- Molecular Weight:175.11
386704-04-7
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$21.00/250mg
386704-12-7
176 suppliers
$6.00/100mg
Yield:386704-12-7 95%
Reaction Conditions:
with manganese(IV) oxide in dichloromethane at 0 - 20;
Steps:
Intermediate 174: 6-(trifluoromethyl)nicotinaldehvde; To a solution of 800 mg of 6-(trifluoromethyl)pyridin-3-yl)methanol (intermediate 173, 4.52 mmole) in 50 mL of DCM cooled at 00C, were added 2 g of MnO2 (23 mmole). The mixture was stirred at RT overnight. The solution was filtered and concentrated on standing at RT to give the title compound (750 mg, 95%) as white solid. 1H-NMR (CDCI3) δ: 7.88-7.90 (1 H, d), 8.36-8.38 (1 H, d), 9.20 (1 H, s), 10.22 (1 H, s); TLC (DCM/MeOH 10:1 ): Rf=0.9.
References:
GLAXO GROUP LIMITED WO2008/148853, 2008, A1 Location in patent:Page/Page column 182
416852-53-4
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386704-12-7
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$6.00/100mg
107-31-3
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436799-32-5
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$5.00/250mg
386704-12-7
176 suppliers
$6.00/100mg
20461-86-3
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436799-32-5
318 suppliers
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386704-12-7
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$6.00/100mg
231291-22-8
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386704-12-7
176 suppliers
$6.00/100mg