2-Trifluoromethyl-5-bromopyridine synthesis
- Product Name:2-Trifluoromethyl-5-bromopyridine
- CAS Number:436799-32-5
- Molecular formula:C6H3BrF3N
- Molecular Weight:225.99
624-28-2
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$5.00/5g
680-15-9
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$13.00/5g
436799-32-5
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$5.00/250mg
Yield:436799-32-5 73%
Reaction Conditions:
with copper(l) iodide in N,N-dimethyl-formamide at 100; for 12 h;
Steps:
30.1 Step 1: Synthesis of 5-bromo-2-(trifluoromethyl)pyridine
Step 1:
Synthesis of 5-bromo-2-(trifluoromethyl)pyridine
To a stirred solution of 2,5-dibromopyridine (0.1 g, 0.421 mmol) in DMF (5.0 mL) was added Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate (0.405 g, 2.109 mmol) along with CuI (0.401 g, 2.109 mmol) and stirred at 100° C. for 12 h.
Completion of reaction was monitored by TLC.
Reaction mass was cooled to room temperature, diluted with water, extracted with EtOAc.
Organic portions were combined, dried over Na2SO4, evaporated under reduced pressure to obtain crude product 5-bromo-2-(trifluoromethyl)pyridine (0.07 g, 73%) as light yellow oil which was directly carry forward for next step.
MS: 227.28[M++1]
References:
Mankind Pharma Ltd.;Patil, Rakesh Ishwar;Verma, Jeevan;Shah, Dharmesh;Ali, Sazid;Bapuram, Srinivasa Reddy;Rai, Santosh Kumar;Kumar, Anil US2017/291910, 2017, A1 Location in patent:Paragraph 0577-0579
383-62-0
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223463-13-6
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436799-32-5
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$5.00/250mg
223463-13-6
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81290-20-2
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436799-32-5
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$5.00/250mg
106877-33-2
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436799-32-5
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2314-97-8
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223463-13-6
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7440-66-6
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436799-32-5
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$5.00/250mg